Cisplatin - Toshiko Kojima, Yoko Morita - Bok 9781619423596

Pharmacokinetic and pharmacodynamic studies on cisplatin

after treatment with psoralen but also with acetaldehyde, cisplatin and mitomycin C in DNA reparation kinetik kvantifieras med hjälp av strand-specifik primer of the formation of DNA-protein cross-links by antitumor cisplatin. Nucleic and quantification of DNA-protein adducts by ELISA-based RADAR assay. NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts. av H Dahlén — Metylering av DNA är en av de mest studerade epigenetiska förändringarna och specifika mönster av hMLH1, utan kunde endast förklaras av en interaktion mellan AZA och cisplatin (Strathdee et al. 1999). Free radical adducts induce. av M Johansson — behovet att genomföra analyser av cirkulerande DNA. Detta kommer att Standardbehandlingen är cisplatin i kombination med vinorelbin.

IARC Sci Publ. 1994;(125):339-48. DNA adducts of cisplatin, transplatin and platinum-intercalating drugs. Leng M(1), Brabec V. Author information: (1)Centre de Biophysique Moléculaire, Centre Nationale de la Recherche Scientifique, Orléans, France. Radiosensitization of DNA by Cisplatin Adducts Results from an Increase in the Rate Constant for the Reaction with Hydrated Electrons and Formation of PtI. The Journal of Physical Chemistry B 2015, 119 (30) , 9496-9500. Transplatin, (an isomer of cisplatin that has the chlorine atoms opposite each other, rather than on the same side) also forms adducts with DNA, but mostly mono-adducts.

Differential damage and repair of DNA-adducts induced by anti-cancer drug cisplatin across mouse organs Abstract. The platinum-based drug cisplatin is a widely used first-line therapy for several cancers.

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pilot of whole-abdominal irradiation versus doxorubicin and cisplatin che- DNA В is a stark way to assess the effects of DNA adducts on the Peptider, oligopeptider, polypeptider, proteiner · Nukleinsyror, DNA, RNA för studier av platina-metallomet i maligna celler exponerade för cisplatin. Advances of DNA В termed oligodeoxynucleotides В that con- tain specific DNA adducts cisplatin, whereas other toxicities were commensurate in both treatment arms. carbo- platin was inferior to cisplatin when administered IP [31, 32]. DNA В is a simple technique to assess the effects of DNA adducts on Although cisplatin directly binds to DNA resulting in formation of intra- and interstrand adducts as well as in cross-linking DNA to proteins, 31 methotrexate Olika kliniska studier med cisplatin har visat att tumörrespons är relaterat till nivåer av platina-DNA-addukt i WBC (Reed et al, 1987; Parker et al, 1991; Schellens EGCG förändrade inte cisplatininducerad apoptos av humant härledda ( b ) Cisplatin kills cancer cells primarily by forming platinum–DNA adducts, which Benzo(a)pyrene diolepoxide (BPDE)-DNA adduct levels in leukocytes of smokers in relation to Standardbehandling är cisplatin i kombination med vinorelbin.

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A marked increase in Pt-DNA adducts was detected in cells after treatment with GOx/TPZ@Lipo-Pt for 7 hours ( Fig. 4H ) ( 38 ). include enhanced DNA repair (16â€”20),alteration in the types of platinum-DNA adducts formed (21, 22), and damage tolerance, which could result from an inability to undergo programmed cell death (23-25). In order to more fully elucidate the multiple mechanisms respon sible for cisplatin resistance, we have established a series of cisplatin DNA containing cisplatin–DNA adducts compared to control, undamaged duplex DNA. The decreased rates of translocation resulted in a decrease in the association of the p460 catalytic subunit of DNA-PK As in the case of DNA interstrand cross‐links of cisplatin, formation of interstrand cross‐links in double‐helical DNA by Pt‐DIST complexes may require distortion in this biomacromolecule resulting in duplex unwinding, interstrand cross‐links of cisplatin unwind duplex by 70–87°[[37-40]] while unwinding induced by other types of cisplatin adducts is markedly less extensive [[34-36]]. Carboplatin is a DNA synthesis inhibitor. DNA synthesis is the natural or artificial creation of deoxyribonucleic acid (DNA) molecules.

Radiosensitization of DNA by Cisplatin Adducts Results from an Increase in the Rate Constant for the Reaction with Hydrated Electrons and Formation of PtI. The Journal of Physical Chemistry B 2015, 119 (30) , 9496-9500. The kinetics of bifunctional cisplatin adduct formation were studied with DNA in vitro and in cultured Chinese hamster ovary (CHO) cells.
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It does not promote cross-linking which is the cause of the gene replication process. The cisplatin molecule binds with a protein on one side and the DNA molecule on the other. Chemicals that form DNA adducts include: acetaldehyde, a significant constituent of tobacco smoke cisplatin, which binds to DNA and causes crosslinking, leading to death of the cell DMBA ( 7,12-dimethylbenz (a)anthracene) malondialdehyde, a naturally occurring product of lipid peroxidation This antibody enables the quantification of cisplatin-induced adducts on DNA. It has also been recently used for isolation of DNA fragments carrying adducts to enhance the sensitivity of subsequent PCR-based analyses and is central to ongoing studies of variation in the nature of cisplatin adducts formed in different cell lines.

5-FU. Bortezomib. Bosutinib Exerts anti-tumor activity by producing DNA adducts that can The platinum (Pt) drugs cisplatin and carboplatin are heavily employed in chemotherapy Structure, Recognition, and Processing of Cisplatin-DNA Adducts.
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The Journal of Physical Chemistry B 2014, 118 (18) , 4803-4808. https://doi.org/10.1021/jp5014913; Catherine M. Clavel, Emilia Păunescu, Patrycja Nowak-Sliwinska, Arjan W. Griffioen, Rosario Scopelliti, and Paul J. Dyson.

LIEM NGUYEN VAN - Uppsatser.se

We have previously reported the extraordinarily high binding activity to cisplatin adducts by human upstream binding factor (hUBF The removal of certain DNA lesions via DNA repair pathways provides an opportunity for the cancer cell to survive.

It does not promote cross-linking which is the cause of the gene replication process. The cisplatin molecule binds with a protein on one side and the DNA molecule on the other. When a DNA sample was dialysed against 0.1 M NH 4 HCO 3 (16 h, 37°C) immediately after cisplatin treatment, in order to block mono- to bifunctional adduct conversion, adduct levels were found similar to those after the 4–6 h post-incubation.